Int J Tuberc Lung Dis. 2011 Jul;15(7):990-2.

Low-level rifampicin-resistant Mycobacterium tuberculosis strains raise a new therapeutic challenge.

van Ingen J, Aarnoutse R, de Vries G, Boeree MJ, van Soolingen D.

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Department of Pulmonary Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. jakko.vaningen@gmail.com

Abstract

In an outbreak of multidrug-resistant tuberculosis, the outbreak strain had an Asp516Tyr rpoB gene mutation. Phenotypically, low-level rifampicin (RMP) resistance (minimum inhibitory concentration [MIC] 1-2 mg/l) was observed. Based on drug susceptibility test results, three patients were treated with 12-15 month rifabutin-based regimens and one with a 12-month RMP-based regimen. We retrospectively performed pharmacokinetic calculations to assess the potential for RMP treatment, from which we conclude that MICs for RMP up to 1 μg/ml may be safely overcome by applying 20 mg/kg RMP doses in treatment regimens.

PMID:: 21682979; [PubMed - indexed for MEDLINE]

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