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    Int J Tuberc Lung Dis. 2011 Jul;15(7):988-9.

    Xpert MTB/RIF®, a novel automated polymerase chain reaction-based tool for the diagnosis of tuberculosis.

    Bowles EC, Freyée B, van Ingen J, Mulder B, Boeree MJ, van Soolingen D.

    Source

    Department of Clinical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.

    Abstract

    There is an urgent need for new point of care tests for tuberculosis (TB). Xpert MTB/RIF® is a real-time polymerase chain reaction-based system that detects Mycobacterium tuberculosis DNA and rifampicin (RMP) resistance modulating mutations directly from clinical samples in 2 h. The sensitivity for detecting M. tuberculosis in culture-positive samples was 93.8% (60/64) and exceeded smear microscopy (40/64, 62.5%). The specificity for detecting M. tuberculosis was 92.0% (23/25) and for RMP resistance it was 100% (8/8). The test is simple to conduct and requires basic sputum handling facilities only. These characteristics render it a promising close-to-patient test for TB in various settings.

    PMID:
    21682978
    [PubMed - indexed for MEDLINE]

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