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    Org Lett. 2011 Jul 15;13(14):3726-9. doi: 10.1021/ol201383w. Epub 2011 Jun 17.

    The missing C-17 O-methyltransferase in geldanamycin biosynthesis.

    Yin M, Lu T, Zhao LX, Chen Y, Huang SX, Lohman JR, Xu LH, Jiang CL, Shen B.

    Source

    Yunnan Institute of Microbiology, Yunnan University, Kunming, Yunnan 650091, China.

    Abstract

    The biosynthetic gene clusters for the Hsp90 inhibitor geldanamycin (GDM, 1) have been cloned previously from three different Streptomyces strains, but the gene encoding the C-17 O-methyltransferase remains unknown. The cloning and sequencing of a new GDM biosynthetic gene cluster from Streptomyces autolyticus CGMCC 0516 was reported, identifying the gdmMT gene that encodes the missing C-17 O-methyltransferase for 1 biosynthesis.

    © 2011 American Chemical Society

    PMID:
    21682254
    [PubMed - indexed for MEDLINE]

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