Abstract
Recently, poly(ester urethanes) were investigated for use as ligament grafts due to their exceptional mechanical properties and highly tunable structure; however, these grafts are susceptible to hydrolytic degradation that occurs independent of tissue regeneration. To address this limitation, polyureas containing collagen-derived peptides were synthesized which enable cellular release of proteases to dictate degradation rate. It is hypothesized that this cell-responsive design will facilitate load transfer from the biodegradable scaffold to neotissue at a rate that promotes proper tissue orientation and function while maintaining construct integrity.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Biocompatible Materials / chemical synthesis*
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Biocompatible Materials / metabolism
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Biocompatible Materials / pharmacology
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Collagen / metabolism*
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Collagenases / metabolism*
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Cross-Linking Reagents / chemistry
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Guided Tissue Regeneration / methods*
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Humans
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Ligaments / drug effects
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Ligaments / injuries
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Ligaments / physiology
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Magnetic Resonance Spectroscopy
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Polyethylene Glycols / chemistry
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Polymers / chemical synthesis*
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Polymers / metabolism
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Polymers / pharmacology
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Proteolysis
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Tissue Engineering / methods*
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Tissue Scaffolds / chemistry*
Substances
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Biocompatible Materials
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Cross-Linking Reagents
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Polymers
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polyurea
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Polyethylene Glycols
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Collagen
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Collagenases