Synthesis of collagenase-sensitive polyureas for ligament tissue engineering

Macromol Biosci. 2011 Aug 11;11(8):1020-30. doi: 10.1002/mabi.201100063. Epub 2011 Jun 16.

Abstract

Recently, poly(ester urethanes) were investigated for use as ligament grafts due to their exceptional mechanical properties and highly tunable structure; however, these grafts are susceptible to hydrolytic degradation that occurs independent of tissue regeneration. To address this limitation, polyureas containing collagen-derived peptides were synthesized which enable cellular release of proteases to dictate degradation rate. It is hypothesized that this cell-responsive design will facilitate load transfer from the biodegradable scaffold to neotissue at a rate that promotes proper tissue orientation and function while maintaining construct integrity.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Biocompatible Materials / chemical synthesis*
  • Biocompatible Materials / metabolism
  • Biocompatible Materials / pharmacology
  • Collagen / metabolism*
  • Collagenases / metabolism*
  • Cross-Linking Reagents / chemistry
  • Guided Tissue Regeneration / methods*
  • Humans
  • Ligaments / drug effects
  • Ligaments / injuries
  • Ligaments / physiology
  • Magnetic Resonance Spectroscopy
  • Polyethylene Glycols / chemistry
  • Polymers / chemical synthesis*
  • Polymers / metabolism
  • Polymers / pharmacology
  • Proteolysis
  • Tissue Engineering / methods*
  • Tissue Scaffolds / chemistry*

Substances

  • Biocompatible Materials
  • Cross-Linking Reagents
  • Polymers
  • polyurea
  • Polyethylene Glycols
  • Collagen
  • Collagenases