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J Med Microbiol. 2011 Oct;60(Pt 10):1496-501. doi: 10.1099/jmm.0.021907-0. Epub 2011 Jun 16.

Molecular epidemiology of mumps virus strains circulating in south-west China from 2007 to 2009.

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  • 1Institute of Medical Biology, Chinese Academy of Medicine Science, Kunming 650118, PR China.

Abstract

The genetic characteristics of mumps virus (MuV) strains isolated from sporadic mumps cases between 2007 and 2009 in three provinces of south-west China were investigated. MuV detection was carried out by nested RT-PCR on 117 cases. The small hydrophobic gene of 33 isolated strains was identified, and sequence analysis revealed that all the isolates belonged to the lineage genotype F with slight nucleotide variation. Furthermore, the virus haemagglutinin-neuraminidase and nucleoprotein antigens exhibited a high degree of nucleotide and amino acid similarity (>99 %) within all isolates, whilst the fusion protein appeared to have certain geographical differences. This study on molecular surveillance will help to monitor the circulation of MuV in China.

PMID:
21680769
[PubMed - indexed for MEDLINE]
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