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Diabetes Care. 2011 Aug;34(8):1785-7. doi: 10.2337/dc11-0641. Epub 2011 Jun 16.

Validation of the Diabetes Prevention Trial-Type 1 Risk Score in the TrialNet Natural History Study.

Author information

  • 1University of Miami, Miami, FL, USA. jsosenko@med.miami.edu

Abstract

OBJECTIVE:

We assessed the accuracy of the Diabetes Prevention Trial-Type 1 Risk Score (DPTRS), developed from the Diabetes Prevention Trial-Type 1 (DPT-1), in the TrialNet Natural History Study (TNNHS).

RESEARCH DESIGN AND METHODS:

Prediction accuracy of the DPTRS was assessed with receiver-operating characteristic curve areas. The type 1 diabetes cumulative incidence within the DPTRS intervals was compared between the TNNHS and DPT-1 cohorts.

RESULTS:

Receiver-operating characteristic curve areas for the DPTRS were substantial in the TNNHS (P < 0.001 at both 2 and 3 years). The type 1 diabetes cumulative incidence did not differ significantly between the TNNHS and DPT-1 cohorts within DPTRS intervals. In the TNNHS, 2-year and 3-year risks were low for DPTRS intervals <6.50 (<0.10 and <0.20, respectively). Thresholds ≥7.50 were indicative of high risk in both cohorts (2-year risks: 0.49 in the TNNHS and 0.51 in DPT-1).

CONCLUSIONS:

The DPTRS is an accurate and robust predictor of type 1 diabetes in autoantibody-positive populations.

PMID:
21680724
[PubMed - indexed for MEDLINE]
PMCID:
PMC3142063
Free PMC Article

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