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J Nucl Med. 2011 Jul;52(7):1068-72. doi: 10.2967/jnumed.110.085944. Epub 2011 Jun 16.

Mapping of lymphatic drainage from the prostate using filtered 99mTc-sulfur nanocolloid and SPECT/CT.

Author information

  • 1Department of Radiology and Biomedical Imaging, University of California, San Francisco, California 94107-1739, USA. youngho.seo@ucsf.edu

Erratum in

  • J Nucl Med. 2013 Aug;54(8):1512.

Abstract

We have developed a practice procedure for prostate lymphoscintigraphy using SPECT/CT and filtered (99m)Tc-sulfur nanocolloid, as an alternative to the proprietary product (99m)Tc-Nanocoll, which is not approved in the United States.

METHODS:

Ten patients were enrolled for this study, and all received radiotracer prepared using a 100-nm membrane filter at a commercial radiopharmacy. Whole-body scans and SPECT/CT studies were performed within 1.5-3 h after the radiotracer had been administered directly into 6 locations of the prostate gland under transrectal ultrasound guidance. The radiation dose was estimated from the first 3 patients. Lymphatic drainage mapping was performed, and lymph nodes were identified.

RESULTS:

The estimated radiation dose ranged from 3.9 to 5.2 mSv/MBq. The locations of lymph nodes draining the prostate gland were similar to those found using the proprietary product.

CONCLUSION:

When the proprietary radiolabeled nanocolloid indicated for lymphoscintigraphy is not available, prostate lymph node mapping and identification are still feasible using filtered (99m)Tc-sulfur nanocolloid.

PMID:
21680690
[PubMed - indexed for MEDLINE]
PMCID:
PMC3129454
Free PMC Article
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