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Reprod Toxicol. 2011 Jul;32(1):85-92. doi: 10.1016/j.reprotox.2011.05.006. Epub 2011 Jun 6.

Trans-resveratrol inhibits phosphorylation of Smad2/3 and represses FSHβ gene expression by a SirT1-independent pathway in LβT2 gonadotrope cells.

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  • 1Department of Medicine, University of California, 9500 Gilman Drive, La Jolla, San Diego, CA 92093, USA.

Abstract

Resveratrol (trans-3,5,4'-trihydroxystilbene), a polyphenol found in red wine, has multiple beneficial activities that are similar to caloric restriction. In this study, we analyzed the effect of resveratrol on the gonadotropin genes, follicle-stimulating hormone (FSHβ) and luteinizing hormone (LHβ) in LβT2 immortalized mouse gonadotrope cells. Resveratrol specifically inhibited activin-induced FSHβ mRNA and protein expression, and reduced activin-stimulated Smad2/3 phosphorylation. Knockdown of SirT1 gene expression or SirT1 inhibition did not block repression of FSHβ expression or suppression of Smad2/3 phosphorylation, but did increase p53 acetylation. Taken together, our results suggest that resveratrol down-regulates Smad2/3 phosphorylation and suppresses FSHβ expression via a SirT1-independent pathway.

Published by Elsevier Inc.

PMID:
21679764
[PubMed - indexed for MEDLINE]
PMCID:
PMC3155991
Free PMC Article
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