EMBO J. 1990 Sep;9(9):2891-8.

Yeast MIG1 repressor is related to the mammalian early growth response and Wilms' tumour finger proteins.

Source

Ludwig Institute for Cancer Research, Uppsala Branch Center, Sweden.

Abstract

We have cloned a yeast gene, MIG1, which encodes a C2H2 zinc finger protein involved in glucose repression. The fingers of MIG1 are very similar to those present in the mammalian Egr finger proteins, which are induced during the early growth response, and also to the finger protein encoded by a human gene that is deleted in Wilms' tumour cells. MIG1 protein binds to two sites in the upstream region of SUC2, a yeast gene that is repressed by glucose. The MIG1 sites closely resemble the sequence recognized by the Egr proteins. Thus, finger proteins that are similar in both amino acid sequence and DNA specificity are involved in the response of yeast to glucose, and in the mammalian early growth response.

PMID:: 2167835; [PubMed - indexed for MEDLINE]
PMCID:: PMC552004

Free PMC Article

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Yeast SKO1 gene encodes a bZIP protein that binds to the CRE motif and acts as a repressor of transcription. [Nucleic Acids Res. 1992]
Yeast SKO1 gene encodes a bZIP protein that binds to the CRE motif and acts as a repressor of transcription.
Nehlin JO, Carlberg M, Ronne H. Nucleic Acids Res. 1992 Oct 25; 20(20):5271-8.
Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. [Cell. 1990]
Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus.
Call KM, Glaser T, Ito CY, Buckler AJ, Pelletier J, Haber DA, Rose EA, Kral A, Yeger H, Lewis WH. Cell. 1990 Feb 9; 60(3):509-20.
Importance of a flanking AT-rich region in target site recognition by the GC box-binding zinc finger protein MIG1. [Mol Cell Biol. 1994]
Importance of a flanking AT-rich region in target site recognition by the GC box-binding zinc finger protein MIG1.
Lundin M, Nehlin JO, Ronne H. Mol Cell Biol. 1994 Mar; 14(3):1979-85.
Review The role of Wilms' tumor genes. [J Med Invest. 1999]
Review The role of Wilms' tumor genes.
Hirose M. J Med Invest. 1999 Aug; 46(3-4):130-40.
Review Wilms' tumour--a case of disrupted development. [J Cell Sci Suppl. 1994]
Review Wilms' tumour--a case of disrupted development.
Miyagawa K, Kent J, Schedl A, van Heyningen V, Hastie ND. J Cell Sci Suppl. 1994; 18:1-5.

See reviews... See all...

Cited by over 100 PubMed Central articles

Application of structure equation modeling for inferring a serial transcriptional regulation in yeast. [Gene Regul Syst Bio. 2011]
Application of structure equation modeling for inferring a serial transcriptional regulation in yeast.
Aburatani S. Gene Regul Syst Bio. 2011; 5:75-88. Epub 2011 Nov 10.
The nuclear pore complex mediates binding of the Mig1 repressor to target promoters. [PLoS One. 2011]
The nuclear pore complex mediates binding of the Mig1 repressor to target promoters.
Sarma NJ, Buford TD, Haley T, Barbara-Haley K, Santangelo GM, Willis KA. PLoS One. 2011; 6(11):e27117. Epub 2011 Nov 14.
Identification of the CRE-1 cellulolytic regulon in Neurospora crassa. [PLoS One. 2011]
Identification of the CRE-1 cellulolytic regulon in Neurospora crassa.
Sun J, Glass NL. PLoS One. 2011; 6(9):e25654. Epub 2011 Sep 29.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Yeast MIG1 repressor is related to the mammalian early growth response and Wilms...
Yeast MIG1 repressor is related to the mammalian early growth response and Wilms' tumour finger proteins.
EMBO J. 1990 Sep ;9(9):2891-8.

PubMed
Weight reduction for non-alcoholic fatty liver disease.
Weight reduction for non-alcoholic fatty liver disease.
Cochrane Database Syst Rev. 2011 Jun 15 ;(6):CD003619.

PubMed
How does a vacation from work affect employee health and well-being?
How does a vacation from work affect employee health and well-being?
Psychol Health. 2011 Dec ;26(12):1606-22. Epub 2011 Jun 28 .

PubMed
Simultaneous assessment of intestinal permeability and lactose tolerance with or...
Simultaneous assessment of intestinal permeability and lactose tolerance with orally administered raffinose, lactose and L-arabinose.
Clin Sci (Lond). 1990 Aug ;79(2):175-83.

PubMed
Current status of genome-wide association studies in cancer.
Current status of genome-wide association studies in cancer.
Hum Genet. 2011 Jul ;130(1):59-78. Epub 2011 Jun 16 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Yeast MIG1 repressor is related to the mammalian early growth response and Wilms' tumour finger proteins.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by over 100 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information