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Molecules. 2011 Jun 15;16(6):4912-22. doi: 10.3390/molecules16064912.

Directed formation of DNA nanoarrays through orthogonal self-assembly.

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  • 1School of Chemistry, University of Southampton, Highfield, Southampton SO171BJ, UK.


We describe the synthesis of terpyridine modified DNA strands which selectively form DNA nanotubes through orthogonal hydrogen bonding and metal complexation interactions. The short DNA strands are designed to self-assemble into long duplexes through a sticky-end approach. Addition of weakly binding metals such as Zn(II) and Ni(II) induces the formation of tubular arrays consisting of DNA bundles which are 50-200 nm wide and 2-50 nm high. TEM shows additional long distance ordering of the terpy-DNA complexes into fibers.

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