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Epilepsy Res. 2011 Sep;96(1-2):116-22. doi: 10.1016/j.eplepsyres.2011.05.011. Epub 2011 Jun 14.

A novel implanted device to wirelessly record and analyze continuous intracranial canine EEG.

Author information

  • 1Department of Neurology, University of Pennsylvania, United States; Penn Epilepsy Center, United States. Kathryn.Davis@uphs.upenn.edu

Abstract

We present results from continuous intracranial electroencephalographic (iEEG) monitoring in 6 dogs with naturally occurring epilepsy, a disorder similar to the human condition in its clinical presentation, epidemiology, electrophysiology and response to therapy. Recordings were obtained using a novel implantable device wirelessly linked to an external, portable real-time processing unit. We demonstrate previously uncharacterized intracranial seizure onset patterns in these animals that are strikingly similar in appearance to human partial onset epilepsy. We propose: (1) canine epilepsy as an appropriate model for testing human antiepileptic devices and new approaches to epilepsy surgery, and (2) this new technology as a versatile platform for evaluating seizures and response to therapy in the natural, ambulatory setting.

Copyright © 2011 Elsevier B.V. All rights reserved.

PMID:
21676591
[PubMed - indexed for MEDLINE]
PMCID:
PMC3175300
Free PMC Article
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