Format

Send to:

Choose Destination
See comment in PubMed Commons below
Int J Obes (Lond). 2012 Apr;36(4):614-24. doi: 10.1038/ijo.2011.107. Epub 2011 Jun 14.

Multicenter evaluation of an interdisciplinary 52-week weight loss program for obesity with regard to body weight, comorbidities and quality of life--a prospective study.

Author information

  • 1Department of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany. bischoff.stephan@uni-hohenheim.de

Abstract

OBJECTIVES:

To determine the effectiveness of a structured multidisciplinary non-surgical obesity therapy program on the basis of a temporary low-calorie-diet for 12 weeks, and additional intervention modules to enhance nutritional education, to increase physical activity and to modify eating behavior.

DESIGN:

Prospective multicenter observational study in obese individuals undergoing a medically supervised outpatient-based 52-week treatment in 37 centers in Germany.

SUBJECTS:

A total of 8296 participants with a body mass index (BMI) of >30 kg m(-2) included within 8.5 years.

MEASUREMENTS:

Main outcome measures were body weight loss, waist circumference (WC), blood pressure, quality of life and adverse events.

RESULTS:

In females, initial body weight was reduced after the 1-year-intervention by 19.6 kg (95% confidence intervals 19.2-19.9 kg) and in males by 26.0 kg (25.2-26.8) according to per protocol analysis of 4850 individuals. Intention-to-treat (ITT) analysis revealed a weight reduction of 15.2 kg (14.9-15.6) in females and 19.4 kg (18.7-20.1) in males. Overall, the intervention resulted in mean reduction in WC of 11 cm; it reduced the prevalence of the metabolic syndrome by 50% and the frequency of hypertension from 47 to 29% of all participants (ITT, all P<0.001). The beneficial effects could be documented for up to 3 years and comprised significant improvement of health-related quality of life. The incidence of adverse effects was low; the only event repeatedly observed and possibly related to either the intervention or the underlying disease was biliary disorders.

CONCLUSION:

The present non-surgical intervention program is a highly effective treatment of obesity grades I-III and obesity-related diseases, and therefore, could be a valuable basis for future weight maintenance strategies required for sustained success.

PMID:
21673653
[PubMed - indexed for MEDLINE]
PMCID:
PMC3322430
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Write to the Help Desk