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Neuroscientist. 2012 Aug;18(4):373-85. doi: 10.1177/1073858411410354. Epub 2011 Jun 13.

Frontotemporal dementia: what can the behavioral variant teach us about human brain organization?

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  • 1Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.


The behavioral variant of frontotemporal dementia (bvFTD) slowly undermines emotion, social behavior, personal conduct, and decision making. These deficits occur in concert with focal neurodegeneration that can be quantified with modern structural and functional imaging and neuropathological methods. As a result, studies of bvFTD have helped to clarify brain structures, networks, and neurons that prove critical for normal social-emotional functioning. In this article, the authors review the evolving bvFTD literature and propose a simple, testable network-based working model for understanding bvFTD.

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