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Int J Biol Macromol. 2011 Oct 1;49(3):409-15. doi: 10.1016/j.ijbiomac.2011.05.031. Epub 2011 Jun 2.

Iron/dextran sulfate multilayered microcapsules for controlled release of 10-hydroxycamptothecin.

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  • 1Alkali Soil Natural Environmental Science Center, Northeast Forestry University, Harbin 150040, People's Republic of China.


Stable 10-hydroxycamptothecin (HCPT) microcrystals with a length of about 5-10μm and a ζ-potential of -38.5mV were produced by pH-induced reprecipitation in presence of a stabilizer hydroxypropylmethylcellulose. Sequential layer growth was achieved by the layer-by-layer (LbL) assembly of Fe(3+) and dextran sulfate (DS) on the surface of HCPT microcrystals via both electrostatic interaction and chemical complexation process. The satisfactory drug loading content (67.2±0.82%) as well as high encapsulation efficiency (60.56±0.82%) for four bilayers of Fe(3+)/DS coating was achieved. Both in vitro and in vivo release study revealed that the release time increased as the number of deposited Fe(3+)/DS bilayers increased. These results indicated that such iron-polysaccharide multilayered microcapsules can be a promising approach for the construction of an effective controlled release delivery system of HCPT as well as other drugs with potential cytotoxicity or short half-life time.

Copyright © 2011 Elsevier B.V. All rights reserved.

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