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Trends Microbiol. 2011 Jul;19(7):323-9. doi: 10.1016/j.tim.2011.05.003. Epub 2011 Jun 12.

Biosensors and their applications in microbial metabolic engineering.

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  • 1Joint BioEnergy Institute, 5885 Hollis Street, Emeryville, CA 94608, USA.


Many metabolic pathways in microbial hosts have been created, modified and engineered to produce useful molecules. The titer and yield of a final compound is often limited by the inefficient use of cellular resources and imbalanced metabolism. Engineering sensory-regulation devices that regulate pathway gene expression in response to the environment and metabolic status of the cell have great potential to solve these problems, and enhance product titers and yields. This review will focus on recent developments in biosensor design, and their applications for controlling microbial behavior.

Copyright © 2011. Published by Elsevier Ltd.

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