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J Am Acad Dermatol. 2011 Dec;65(6):1145-51. doi: 10.1016/j.jaad.2010.09.009. Epub 2011 Jun 12.

Supplement use and risk of cutaneous squamous cell carcinoma.

Author information

  • 1Division of Research, Kaiser Permanente Northern California, Oakland, California 94612, USA. maryam.m.asgari@kp.org

Abstract

BACKGROUND:

Laboratory and epidemiologic studies suggest that certain dietary supplements may alter risk of cutaneous squamous cell carcinoma (SCC).

OBJECTIVE:

We sought to examine the association between supplement use and SCC risk.

METHODS:

Cases (n = 415) were defined as Kaiser Permanente Northern California members with a pathology-verified SCC in 2004 and control subjects (n = 415) were age-, sex-, and race-matched members with no history of skin cancer. Supplement use and SCC risk factors were ascertained by questionnaire. Associations of SCC with use of multivitamins; vitamins A, C, D, and E; and grape seed extract were estimated as odds ratios and 95% confidence intervals using conditional logistic regression. Models were adjusted for SCC risk factors and other supplement use.

RESULTS:

Grape seed extract users had a significantly decreased risk of cutaneous SCC (adjusted odds ratio 0.26, confidence interval 0.08-0.89, P = .031). Multivitamin use was associated with a borderline significant reduction in SCC risk (adjusted odds ratio 0.71, confidence interval 0.51-1.00, P = .049). Use of vitamins A, C, D, and E was not associated with SCC risk.

LIMITATIONS:

The data may be prone to recall and selection bias because of the case-control design. No information was obtained on dose or duration of supplement use.

CONCLUSIONS:

Use of grape seed extract may be associated with a decreased risk of cutaneous SCC. The other supplements included in our study did not reveal clear associations with SCC risk.

Copyright © 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

Comment in

PMID:
21664718
[PubMed - indexed for MEDLINE]
PMCID:
PMC3184340
Free PMC Article
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