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Dev Cell. 2011 Jun 14;20(6):775-87. doi: 10.1016/j.devcel.2011.04.018.

Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function.

Author information

  • 1Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, 48109, USA. benallen@umich.edu

Abstract

Secreted Hedgehog (HH) ligands signal through the canonical receptor Patched (PTCH1). However, recent studies implicate three additional HH-binding, cell-surface proteins, GAS1, CDO, and BOC, as putative coreceptors for HH ligands. A central question is to what degree these coreceptors function similarly and what their collective requirement in HH signal transduction is. Here we provide evidence that GAS1, CDO, and BOC play overlapping and essential roles during HH-mediated ventral neural patterning of the mammalian neural tube. Specifically, we demonstrate two important roles for these molecules: an early role in cell fate specification of multiple neural progenitors and a later role in motor neuron progenitor maintenance. Most strikingly, genetic loss-of-function experiments indicate an obligatory requirement for GAS1, CDO, and BOC in HH pathway activity in multiple tissues.

Copyright © 2011 Elsevier Inc. All rights reserved.

PMID:
21664576
[PubMed - indexed for MEDLINE]
PMCID:
PMC3121104
Free PMC Article

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