Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Environ Res. 2011 Aug;111(6):831-7. doi: 10.1016/j.envres.2011.05.016. Epub 2011 Jun 12.

Serum PBDEs and age at menarche in adolescent girls: analysis of the National Health and Nutrition Examination Survey 2003-2004.

Author information

  • 1Division of Epidemiology and Biostatistics, Department of Environmental Health, University of Cincinnati College of Medicine, P.O. Box 670056, Cincinnati, OH 45267-0056, USA. aimin.chen@uc.edu

Abstract

BACKGROUND:

Polybrominated diphenyl ethers (PBDEs), widely used as flame retardants since the 1970s, have exhibited endocrine disruption in experimental studies. Tetra- to hexa-BDE congeners are estrogenic, while hepta-BDE and 6-OH-BDE-47 are antiestrogenic. Most PBDEs also have antiandrogenic activity. It is not clear, however, whether PBDEs affect human reproduction.

OBJECTIVES:

The analysis was designed to investigate the potential endocrine disruption of PBDEs on the age at menarche in adolescent girls.

METHODS:

We analyzed the data from a sample of 271 adolescent girls (age 12-19 years) in the National Health and Nutrition Examination Survey (NHANES), 2003-2004. We estimated the associations between individual and total serum BDEs (BDE-28, -47, -99, -100, -153, and -154, lipid adjusted) and mean age at menarche. We also calculated the risk ratios (RRs) and 95% confidence intervals (CI) for menarche prior to age 12 years in relation to PBDE exposure.

RESULTS:

The median total serum BDE concentration was 44.7ng/g lipid. Higher serum PBDE concentrations were associated with slightly earlier ages at menarche. Each natural log unit of total BDEs was related to a change of -0.10 (95% CI: -0.33, 0.13) years of age at menarche and a RR of 1.60 (95% CI: 1.12, 2.28) for experiencing menarche before 12 years of age, after adjustment for potential confounders.

CONCLUSION:

These data suggest high concentrations of serum PBDEs during adolescence are associated with a younger age of menarche.

Copyright © 2011 Elsevier Inc. All rights reserved.

PMID:
21663902
[PubMed - indexed for MEDLINE]
PMCID:
PMC3143295
Free PMC Article

Images from this publication.See all images (1)Free text

Figure 1
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk