Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cell. 2011 Jun 10;145(6):835-50. doi: 10.1016/j.cell.2011.05.019.

Chromatin connections to pluripotency and cellular reprogramming.

Author information

  • 1Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA. stuart_orkin@dfci.harvard.edu

Abstract

The pluripotent state of embryonic stem cells (ESCs) provides a unique perspective on regulatory programs that govern self-renewal and differentiation and somatic cell reprogramming. Here, we review the highly connected protein and transcriptional networks that maintain pluripotency and how they are intertwined with factors that affect chromatin structure and function. The complex interrelationships between pluripotency and chromatin factors are illustrated by X chromosome inactivation, regulatory control by noncoding RNAs, and environmental influences on cell states. Manipulation of cell state through the process of transdifferentiation suggests that environmental cues may direct transcriptional programs as cells enter a transiently "plastic" state during reprogramming.

Copyright © 2011 Elsevier Inc. All rights reserved.

PMID:
21663790
[PubMed - indexed for MEDLINE]
PMCID:
PMC4858411
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk