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Cell. 2011 Jun 10;145(6):827-30. doi: 10.1016/j.cell.2011.05.036.

Cell fate plug and play: direct reprogramming and induced pluripotency.

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  • 1Center for Stem Cell Biology, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065, USA.


Building on the discovery that MyoD expression reprograms fibroblasts into muscle, three papers (Vierbuchen et al., 2010; Ieda et al., 2010; Szabo et al., 2010) recently reported the reprogramming of fibroblasts into neurons, cardiomyocytes, and blood cell progenitors without first passing the cells through a pluripotent state. Here we discuss the advantages and challenges of harnessing this direct reprogramming method for regenerative medicine.

Copyright © 2011 Elsevier Inc. All rights reserved.

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