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Cell. 2011 Jun 10;145(6):815-7. doi: 10.1016/j.cell.2011.05.027.

Rolling ES cells down the Waddington landscape with Oct4 and Sox2.

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  • 1Institut de Génétique Humaine, CNRS, 141 rue de la Cardonille, 34396 Montpellier, France.


Embryonic stem cell (ESC) pluripotency is maintained by core transcriptional circuits whereby critical factors sustain their own expression while preventing the expression of genes required for differentiation. Thomson et al. (2011) now show that two core components of the pluripotency circuit, Oct4 and Sox2, are also critical for germ layer fate choice.

Copyright © 2011 Elsevier Inc. All rights reserved.

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