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Trends Biochem Sci. 1990 Jun;15(6):222-7.

Bending and supercoiling of DNA at the attachment site of bacteriophage lambda.

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  • 1Laboratory of Molecular Biology, National Institute of Mental Health, Bethesda, MD 20892.


Integration of the DNA of bacteriophage lambda into the chromosome of E. coli depends on the formation of a complex nucleoprotein array at a specific locus on the phage genome, the attachment site. Recent work shows how bending of this DNA (induced by a specific DNA-binding protein), and strain in this DNA (induced by supercoiling) contribute to the formation of the nucleoprotein structure. Further, there are new insights into the way this structure directs critical events during recombination.

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