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BMC Gastroenterol. 2011 Jun 10;11:68. doi: 10.1186/1471-230X-11-68.

Schwann cell hamartoma: case report.

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  • 1Department of Medicine, Surgery and Dentistry, Division of Pathology, A,O, San Paolo and Fondazione IRCCS Cà-Granda Ospedale Maggiore Policlinico, University of Milan Medical School, Milan, Italy.

Abstract

BACKGROUND:

Colorectal polyps of mesenchymal origin represent a small percentage of gastrointestinal (GI) lesions. Nevertheless, they are encountered with increasing frequency since the widespread adoption of colonoscopy screening.

CASE PRESENTATION:

We report a case of a small colonic polyp that presented as intramucosal diffuse spindle cell proliferation with a benign cytological appearance, strong and diffuse immunoreactivity for S-100 protein, and pure Schwann cell phenotype. Careful morphological, immunohistochemical and clinical evaluation emphasize the differences from other stromal colonic lesions and distinguish it from schwannoma, a circumscribed benign nerve sheath tumor that rarely arises in the GI tract.

CONCLUSION:

As recently proposed, this lesion was finally described as mucosal Schwann cell hamartoma.

PMID:
21663626
[PubMed - indexed for MEDLINE]
PMCID:
PMC3123296
Free PMC Article
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