Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Adv Exp Med Biol. 2011;712:100-15. doi: 10.1007/978-1-4419-8414-2_7.

Cruzain : the path from target validation to the clinic.

Author information

  • 1Afd. Parasitologie, Leiden University Medical Center, Leiden, The Netherlands.

Abstract

Cruzain is the major papain-like cysteine protease of Trypanosoma cruzi, the etiological agent causing Chagas' disease in humans in South America. Cruzain is indispensable for the survival and propagation of this protozoan parasite and therefore, it has attracted considerable interest as a potential drug target. This chapter charts the path from the initial identification of this proteases activity and its validation as a bone fide drug target to the arduous task of the discovery of an inhibitor targeting this protease and finally the path towards the clinic.

PMID:
21660661
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Springer
    Loading ...
    Write to the Help Desk