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Leuk Lymphoma. 2011 Sep;52(9):1655-67. doi: 10.3109/10428194.2011.575493. Epub 2011 Jun 10.

Follicular lymphoma: still Six characters in search of an author?

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  • 1Hematopathology Section, Department of Hematology and Oncology L and A Seràgnoli, S Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.


Follicular lymphoma (FL) is regarded as a distinct entity in the literature as well as in the 2008 edition of the WHO classification of tumours of haematopoietic and lymphoid tissues. Nevertheless, there are still several issues that are matters of controversy such as the grading system or the exact biological location of grade 3B FL. This makes FL somewhat like the Six characters in search of an author of Pirandello's comedy. Here, we revise the morphology and pathobiology of FL by highlighting both the areas remaining critical and future perspectives. This review was inspired by the reappraisal of Professor Lennert's personal archive that represents a unique legacy for the entire scientific community.

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