Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Proc Natl Acad Sci U S A. 1990 Aug;87(15):5697-701.

Mitotic role for the Cdc28 protein kinase of Saccharomyces cerevisiae.

Author information

  • 1Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, CA 92037.

Abstract

The Cdc28 protein kinase functions in the G1 to S phase transition of the cell cycle of the budding yeast Saccharomyces cerevisiae. This is in contrast with observations of the homologous protein kinase from a variety of metazoans, where activity and function are associated with the G2 to M phase transition. We present evidence that the Cdc28 protein kinase is also required for mitosis and that this function is executed in the G2 interval of the cell cycle. We show, in addition, that the protein kinase is highly active during this phase of the cell cycle. The dual role of the Cdc28 protein kinase in the S. cerevisiae cell cycle thus parallels that demonstrated for the cdc2 protein kinase of the fission yeast Schizosaccharomyces pombe.

PMID:
2165600
[PubMed - indexed for MEDLINE]
PMCID:
PMC54394
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk