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Chem Soc Rev. 2011 Oct;40(10):5084-121. doi: 10.1039/c1cs15071e. Epub 2011 Jun 8.

Recent advances in Sonogashira reactions.

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  • 1Departamento de Química Orgánica, Facultad de Ciencias and Instituto de Síntesis Orgánica (ISO), Universidad de Alicante, Apartado 99, 03080 Alicante, Spain. chinchilla@ua.es

Abstract

The coupling of aryl or vinyl halides with terminal acetylenes catalysed by palladium and other transition metals, commonly termed as Sonogashira cross-coupling reaction, is one of the most important and widely used sp(2)-sp carbon-carbon bond formation reactions in organic synthesis, frequently employed in the synthesis of natural products, biologically active molecules, heterocycles, molecular electronics, dendrimers and conjugated polymers or nanostructures. This critical review focuses on developments in the Sonogashira reaction achieved in recent years concerning catalysts, reaction conditions and substrates (352 references).

This journal is © The Royal Society of Chemistry 2011

PMID:
21655588
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