Format

Send to:

Choose Destination
See comment in PubMed Commons below
Br J Clin Pharmacol. 2011 Jul;72(1):153-6. doi: 10.1111/j.1365-2125.2011.03941.x.

Possible drug-drug interaction between quetiapine and lamotrigine--evidence from a Swedish TDM database.

Author information

  • 1Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska University Hospital, Huddinge, Karolinska Institutet, 141 86 Stockholm, Sweden. marine.andersson@karolinska.se

Abstract

AIM:

The aim of the present study was to investigate a previously proposed interaction between quetiapine and lamotrigine resulting in reduced serum quetiapine concentrations.

METHODS:

Data on 402 patients subjected to analysis of quetiapine concentration in serum were extracted from a routine therapeutic drug monitoring database. Among these patients, those concomitantly treated with lamotrigine (n= 22) were identified and matched with 22 controls receiving quetiapine while unexposed to lamotrigine. The dose-corrected quetiapine concentrations (C : D ratios) in the two groups were compared in both paired and unpaired analyses.

RESULTS:

Patients co-treated with lamotrigine had a lower mean C : D ratio (0.71, 95% CI 0.46, 0.97) compared with controls (1.64, 95% CI 1.00, 2.28). Dose-corrected quetiapine concentrations were 58% lower in patients co-medicated with lamotrigine.

CONCLUSIONS:

This study indicates that lamotrigine exposure is associated with substantially reduced serum concentrations of quetiapine, possibly due to induced glucuronidation. These findings need to be confirmed in experimental studies.

© 2011 The Authors. British Journal of Clinical Pharmacology © 2011 The British Pharmacological Society.

PMID:
21651616
[PubMed - indexed for MEDLINE]
PMCID:
PMC3141197
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Blackwell Publishing Icon for PubMed Central
    Loading ...
    Write to the Help Desk