Format

Send to

Choose Destination
See comment in PubMed Commons below
Pediatr Rep. 2011 Feb 24;3(1):e1. doi: 10.4081/pr.2011.e1.

Laboratory aid to the diagnosis and therapy of infection in the neonate.

Author information

  • 1Department of Neonatology and Neonatal Intensive Care, Children Hospital, Spedali Civili, Brescia, Italy.

Abstract

Despite the advances in perinatal and neonatal care and use of newer potent antibiotics, the incidence of neonatal sepsis remains high and the outcome is still severe. For years, investigators have sought a test or panel of tests able to identify septic neonates accurately and rapidly in order to obtain an early diagnosis and develop a specific effective treatment for a successful outcome. In addition to the standard procedures (blood, CSF, and urine cultures), such panels have included a combination of haematological investigations (total, differential and immature cell counts), and levels of acute-phase reactants (principally CRP and procalcitonin), and cytokines (such as IL-6 or neutrophil CD64). Furthermore, the science of proteomics and genomics has been applied to the search for bio-markers, production of protein profiles and genetic polymorphisms that can rapidly help the prediction, early diagnosis, and treatment of human diseases, but, for now, data are as yet insufficient to confirm their validity.

KEYWORDS:

IgG antibodies.; neonatal sepsis

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk