Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Pharmacogenomics J. 2012 Oct;12(5):368-71. doi: 10.1038/tpj.2011.23. Epub 2011 Jun 7.

Gene expression in blood is associated with risperidone response in children with autism spectrum disorders.

Author information

  • 1Department of Neurology, University of California, Davis, MIND Institute, Davis, CA 95817, USA. llit@ucdavis.edu

Abstract

Children with autism spectrum disorders (ASDs) often have severe behavioral problems. Not all children with these problems respond to atypical antipsychotic medications; therefore, we investigated whether peripheral blood gene expression before treatment with risperidone, an atypical antipsychotic, was associated with improvements in severe behavioral disturbances 8 weeks following risperidone treatment in 42 ASD subjects (age 112.7±51.2 months). Exon expression levels in blood before risperidone treatment were compared with pre-post risperidone change in Aberrant Behavior Checklist-Irritability (ABC-I) scores. Expression of exons within five genes was correlated with change in ABC-I scores across all risperidone-treated subjects: GBP6, RABL5, RNF213, NFKBID and RNF40 (α<0.001). RNF40 is located at 16p11.2, a region implicated in autism and schizophrenia. Thus, these genes expressed before treatment were associated with subsequent clinical response. Future studies will be needed to confirm these results and determine whether this expression profile is associated with risperidone response in other disorders, or alternative antipsychotic response within ASD.

PMID:
21647175
[PubMed - indexed for MEDLINE]
PMCID:
PMC3175502
Free PMC Article

Images from this publication.See all images (1)Free text

Figure 1
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Write to the Help Desk