Eosinophilic gastrointestinal disorders in infants: a Japanese case series

Int Arch Allergy Immunol. 2011:155 Suppl 1:40-5. doi: 10.1159/000327264. Epub 2011 Jun 1.

Abstract

Background: Eosinophilic gastrointestinal disorders (EGIDs) are disorders characterized by primary eosinophil inflammation in the gastrointestinal tract. There are a small number of reports of eosinophil infiltration in gastrointestinal tracts presenting as EGIDs in infants. In this study, we present Japanese cases of EGIDs in infants.

Methods: Five patients diagnosed with or strongly suspected to have EGIDs in our hospital from 2008 to 2010 were reviewed. Radiographic contrast enema examinations and/or endoscopies were performed in 4 and 3 patients, respectively.

Results: There were patients with eosinophilic colitis (1 suspected and 2 biopsy-proven), a patient who was suspected of having allergic eosinophilic enterocolitis, and a patient with eosinophilic gastroenteritis associated with pediatric hypereosinophilic syndrome.

Conclusions: The causes and clinical findings of patients with intestinal eosinophil inflammation vary. Therefore, deliberate examination and observation are important for patients with infantile EGID.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Colon / pathology
  • Congenital Abnormalities / pathology
  • Constriction, Pathologic / pathology
  • Eczema / complications
  • Enteritis* / blood
  • Enteritis* / complications
  • Enteritis* / diagnosis
  • Enteritis* / etiology
  • Enteritis* / pathology
  • Enteritis* / therapy
  • Eosinophilia* / blood
  • Eosinophilia* / complications
  • Eosinophilia* / diagnosis
  • Eosinophilia* / etiology
  • Eosinophilia* / pathology
  • Eosinophilia* / therapy
  • Eosinophils / pathology
  • Feces / cytology
  • Female
  • Gastric Mucosa / pathology
  • Gastritis* / blood
  • Gastritis* / complications
  • Gastritis* / diagnosis
  • Gastritis* / etiology
  • Gastritis* / pathology
  • Gastritis* / therapy
  • Humans
  • Hypereosinophilic Syndrome / blood
  • Hypereosinophilic Syndrome / complications
  • Hypereosinophilic Syndrome / pathology
  • Immunoglobulin E / blood
  • Immunoglobulin E / immunology
  • Infant
  • Infant, Newborn
  • Intestinal Mucosa / pathology
  • Japan
  • Male
  • Milk Hypersensitivity / complications
  • Milk Hypersensitivity / immunology
  • Myocarditis / complications
  • Occult Blood
  • Prednisolone / therapeutic use
  • Rectum / pathology
  • Syndrome

Substances

  • Immunoglobulin E
  • Prednisolone

Supplementary concepts

  • Eosinophilic enteropathy