Structure. 2011 Jun 8;19(6):751-3. doi: 10.1016/j.str.2011.05.007.

Recombining DNA by protein swivels.

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Department of Biological Chemistry, David Geffen School of Medicine at UCLA, 615 Charles Young Drive South, Los Angeles, CA 90095-1737, USA. rcjohnson@mednet.ucla.edu

Abstract

Two new reports on serine recombinases, one of a crystal snapshot in an alternate rotational conformer poised for DNA cleavage (Keenholtz et al., 2011), and a second employing single-DNA molecule approaches (Bai et al., 2011), provide strong support for the subunit rotation model for exchanging DNA strands.

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Structural basis for catalytic activation of a serine recombinase. [Structure. 2011]
Structural basis for catalytic activation of a serine recombinase.Keenholtz RA, Rowland SJ, Boocock MR, Stark WM, Rice PA. Structure. 2011 Jun 8; 19(6):799-809.
Single-molecule analysis reveals the molecular bearing mechanism of DNA strand exchange by a serine recombinase. [Proc Natl Acad Sci U S A. 2011]
Single-molecule analysis reveals the molecular bearing mechanism of DNA strand exchange by a serine recombinase.Bai H, Sun M, Ghosh P, Hatfull GF, Grindley ND, Marko JF. Proc Natl Acad Sci U S A. 2011 May 3; 108(18):7419-24. Epub 2011 Apr 18.

PMID:: 21645847; [PubMed]

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Cited by 1 PubMed Central article

The site-specific integration reaction of Listeria phage A118 integrase, a serine recombinase. [Mob DNA. 2013]
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Recombining DNA by protein swivels.
Recombining DNA by protein swivels.
Structure. 2011 Jun 8 ;19(6):751-3. doi: 10.1016/j.str.2011.05.007.

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