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Biochim Biophys Acta. 2011 Nov;1811(11):946-60. doi: 10.1016/j.bbalip.2011.05.006. Epub 2011 May 27.

Desorption electrospray ionization mass spectrometry for lipid characterization and biological tissue imaging.

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  • 1Department of Chemistry, Purdue University, West Lafayette, IN, USA.

Abstract

Desorption electrospray ionization mass spectrometry (DESI-MS) imaging of biological samples allows untargeted analysis and structural characterization of lipids ionized from the near-surface region of a sample under ambient conditions. DESI is a powerful and sensitive MS ionization method for 2D and 3D imaging of lipids from direct and unmodified complex biological samples. This review describes the strengths and limitations of DESI-MS for lipid characterization and imaging together with the technical workflow and a survey of applications. Included are discussions of lipid mapping and biomarker discovery as well as a perspective on the future of DESI imaging.

Copyright © 2011 Elsevier B.V. All rights reserved.

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