Blood. 2011 Jul 21;118(3):609-17. Epub 2011 Jun 3.

BAD-LAMP is a novel biomarker of nonactivated human plasmacytoid dendritic cells.

Defays A, David A, de Gassart A, De Angelis Rigotti F, Wenger T, Camossetto V, Brousset P, Petrella T, Dalod M, Gatti E, Pierre P.

Source

Centre d'Immunologie de Marseille-Luminy, Université de la Méditerranée, Marseille, France.

Abstract

The brain and dendritic cell (BAD)-associated lysosome-associated membrane protein (LAMP)-like molecule (BAD-LAMP, c20orf103, UNC-46) is a newly identified member of the family of LAMPs. BAD-LAMP expression in the mouse is confined to neurons. We demonstrate here that in humans, BAD-LAMP can specifically be found in the type I IFN-producing plasmacytoid dendritic cells (pDCs). Human BAD-LAMP is localized in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) of freshly isolated CD123(+) pDCs and is rapidly lost upon activation by unmethylated cytosine-phosphate-guanine (CpG) oligonucleotides. The restricted pattern of BAD-LAMP expression allows for the rapid identification of normal and leukemic human pDCs in tissues and blood.

PMID:: 21642595; [PubMed - indexed for MEDLINE]

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