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ISRN Obstet Gynecol. 2011;2011:426150. doi: 10.5402/2011/426150. Epub 2010 Oct 27.

Breast metastatic localization of signet-ring cell gastric carcinoma.

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  • 1Servicio de Obstetricia y Ginecología, Hospital Marina Baixa, Avenida Alcalde En Jaume Botella Major 7, 03570 Villajoyosa (Alicante), Spain.


Metastatic tumors in the breast are quite rare and constitute 0,5 to 6% of all breast malignancies. They often occur in a polymetastatic context. Gastrointestinal lesions rarely metastasize to the breast. The first case of a metastasis deposit to the breast and ovary from gastric signet-ring cell carcinoma was reported in the literature in 1999. Since this report, only 5 cases have been reported. We present a case report of a 37-year-old woman who complained of a lump in the left breast. Two months earlier, the woman underwent a subtotal gastrectomy and a total hysterectomy with double anexectomy, which histologically was diagnosed of gastric signet-ring carcinoma, disseminated with Krukenberg's tumor. In those days, the patient was following a chemotherapy treatment. A core needle biopsy of the lesion in left breast revealed cells with signet-ring features, with probably gastric origin.

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