Format

Send to:

Choose Destination
See comment in PubMed Commons below
World J Gastroenterol. 2011 May 14;17(18):2326-31. doi: 10.3748/wjg.v17.i18.2326.

LBP and CD14 polymorphisms correlate with increased colorectal carcinoma risk in Han Chinese.

Author information

  • 1Institute of Pathology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.

Abstract

AIM:

To explore the associations of polymorphisms of lipopolysaccharide binding protein (LBP), cluster of differentiation 14 (CD14), toll-like receptor 4 (TLR-4), interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) with the colorectal carcinoma (CRC) risk in Han Chinese.

METHODS:

Polymorphisms of LBP (rs1739654, rs2232596, rs2232618), CD14 (rs77083413, rs4914), TLR-4 (rs5030719), IL-6 (rs13306435) and TNF-α (rs35131721) were genotyped in 479 cases of sporadic colorectal carcinoma and 486 healthy controls of Han Chinese in a case-control study. Single-nucleotide polymorphisms (SNPs) between cases and controls were analyzed by unconditional logistic regression.

RESULTS:

GA and GG genotypes of LBP rs2232596 were associated with a significantly increased risk of CRC [odds ratio (OR) = 1.51, 95% confidence interval (CI) 1.15-1.99, P = 0.003; OR = 2.49, 95% CI 1.16-5.38, P = 0.016, respectively]. A similar association was also observed for the CG genotype of CD14 rs4914 (OR= 1.69, 95% CI 1.20-2.36, P = 0.002). In addition, a combination of polymorphisms in LBP rs2232596 and CD14 rs4914 led to a 3.4-fold increased risk of CRC (OR = 3.44, 95% CI 1.94-6.10, P = 0.000).

CONCLUSION:

This study highlights the LBP rs2232596 and CD14 rs4914 polymorphisms as biomarkers for elevated CRC susceptibility in the Chinese Han population.

KEYWORDS:

Cluster of differentiation 14; Colorectal carcinoma; Lipopolysaccharide binding protein; Single-nucleotide polymorphisms

PMID:
21633598
[PubMed - indexed for MEDLINE]
PMCID:
PMC3098400
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Baishideng Publishing Group Inc. Icon for PubMed Central
    Loading ...
    Write to the Help Desk