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J Clin Invest. 2011 Jun;121(6):2076-9. doi: 10.1172/JCI58719. Epub 2011 Jun 1.

Digging deeper into obesity.

Author information

  • Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, and the Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. ahima@mail.med.upenn.edu

Abstract

The growing problem of obesity is associated with multiple morbidities, including increased risk of diabetes, hypertension, heart disease, sleep apnea, and cancer. Obesity promotes disability, decreases productivity, and shortens life span. Although much attention has been focused on diet and exercise, these strategies alone are not effective in preventing obesity and maintaining weight loss. Moreover, the development of pharmacological approaches for obesity treatment has been dogged by poor efficacy and serious side effects. The biology of obesity is very complex, and mechanisms linking obesity to various diseases are poorly understood. This issue of the JCI highlights important concepts in our understanding of the pathogenesis of obesity and its complications.

PMID:
21633174
[PubMed - indexed for MEDLINE]
PMCID:
PMC3104789
Free PMC Article

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