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    Diabetes Metab Res Rev. 2011 Jun 1. doi: 10.1002/dmrr.1221. [Epub ahead of print]

    GWAS and its impact on elucidating the etiology of diabetes.

    Hakonarson H, Grant SF.

    Source

    The Center for Applied Genomics and Division of Human Genetics, the Abramson Research Center of the Joseph Stokes Jr. Research Institute, The Children's Hospital of Philadelphia; Department of Pediatrics, The University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA. hakonarson@email.chop.edu.

    Abstract

    It has proven to be challenging to isolate the genes underlying the genetic component conferring susceptibility to type 1 and type 2 diabetes. Unlike previous approaches, 'genome wide association studies' (GWAS) have extensively delivered on the promise of uncovering genetic determinants of complex disease, with a number of novel disease-associated variants being largely replicated by independent groups. This review provides an overview of these recent breakthroughs in the context of type 1 and type 2 diabetes, and outlines strategies on how these findings will be applied to impact clinical care for these two highly prevalent disorders. Copyright © 2011 John Wiley & Sons, Ltd.

    Copyright © 2011 John Wiley & Sons, Ltd.

    PMID:
    21630414
    [PubMed - as supplied by publisher]

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