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PLoS One. 2011;6(5):e20266. doi: 10.1371/journal.pone.0020266. Epub 2011 May 23.

Autoantibodies against a 43 KDa muscle protein in inclusion body myositis.

Author information

  • 1Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America. msalajegheh@partners.org

Abstract

BACKGROUND:

Inclusion body myositis (IBM) is a poorly understood and refractory autoimmune muscle disease. Though widely believed to have no significant humoral autoimmunity, we sought to identify novel autoantibodies with high specificity for this disease.

METHODOLOGY/PRINCIPAL FINDINGS:

Plasma autoantibodies from 65 people, including 25 with IBM, were analyzed by immunoblots against normal human muscle. Thirteen of 25 (52%) IBM patient samples recognized an approximately 43 kDa muscle protein. No other disease (N = 25) or healthy volunteer (N = 15) samples recognized this protein.

CONCLUSIONS:

Circulating antibodies against a 43-kDa muscle autoantigen may lead to the discovery of a novel biomarker for IBM. Its high specificity for IBM among patients with autoimmune myopathies furthermore suggests a relationship to disease pathogenesis.

PMID:
21629782
[PubMed - indexed for MEDLINE]
PMCID:
PMC3100335
Free PMC Article
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