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J Clin Med Res. 2010 Aug 18;2(4):185-8. doi: 10.4021/jocmr403w.

Cutaneous granular cell tumor of the breast: a clinical diagnostic pitfall.

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  • 1Department of Pathology, University Hospital, Granada, Spain.


We report the clinical-morphological study of a granular cell tumor in dermal/hypodermal junction and subcutaneous fat left breast of an 83-year-old woman with a family history of breast carcinoma. Mammography study showed a spiculated lesion in the lower inner quadrant with suspicion of malignancy. The results of fine needle puncture-aspiration were inconclusive. Subsequent tumorectomy revealed a poorly-defined indurated lesion of 1.1 x 0.7 cm. The histopathology study showed a proliferation of cells with ample and granular cytoplasm that were positive for S100, CD 68 and inhibin and negative for hormonal receptors. We present a benign lesion that clinically reproduces a breast carcinoma.

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