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Cell Stem Cell. 2011 Jun 3;8(6):604-5. doi: 10.1016/j.stem.2011.05.007.

Epigenetic modifications in distinction: histone versus DNA methylation in ESCs.

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  • 1Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-7088, USA.


In this issue of Cell Stem Cell, Karimi et al. (2011) show that DNA methylation and histone H3 lysine 9 trimethylation (H3K9me3) have distinct genomic targets in mouse ESCs. In particular, loss of H3K9me3 leads to derepression of select endogenous retroviruses and subsequent ectopic transcription of adjacent genes.

Copyright © 2011 Elsevier Inc. All rights reserved.

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