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Int J Pharm. 2011 Oct 14;418(2):243-53. doi: 10.1016/j.ijpharm.2011.05.039. Epub 2011 May 20.

Drawdown of floating solids in stirred tanks: scale-up study using CFD modeling.

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  • 1Bend Research Inc., 64550 Research Rd., Bend, OR 97701, United States.


This work shows development of a scale up correlation using computational fluid dynamic (CFD) simulations for floating solids drawdown operation in stirred tanks. Discrete phase modeling (DPM) simulations were used in conjunction with the lab scale experimental measurements to develop a semi-empirical correlation for the prediction of rate of drawdown of floating solid particles. The rate was correlated to average liquid velocity at the free liquid surface. Since, this correlation is based on a fundamental hydrodynamic parameter, velocity, rather than an operating parameters such as the impeller speed, it can be used for a variety of impeller types and tank geometries. The correlation was developed based on the data obtained from the 2L tank using four different tank designs and was validated against the data obtained from the 10L scale tank. The correlation was further extended to the pilot and the commercial scale tanks ranging from 40L to 4000L scale based solely on the CFD model.

Copyright © 2011 Elsevier B.V. All rights reserved.

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