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FEBS Lett. 2011 Dec 1;585(23):3806-12. doi: 10.1016/j.febslet.2011.05.030. Epub 2011 May 27.

Innate immune responses in central nervous system inflammation.

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  • 1Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.

Abstract

In autoimmune diseases of the central nervous system (CNS), innate glial cell responses play a key role in determining the outcome of leukocyte infiltration. Access of leukocytes is controlled via complex interactions with glial components of the blood-brain barrier that include angiotensin II receptors on astrocytes and immunoregulatory mediators such as Type I interferons which regulate cellular traffic. Myeloid cells at the blood-brain barrier present antigen to T cells and influence cytokine effector function. Myelin-specific T cells interact with microglia and promote differentiation of oligodendrocyte precursor cells in response to axonal injury. These innate responses offer potential targets for immunomodulatory therapy.

Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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