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Nucleic Acids Res. 2011 Jul;39(Web Server issue):W518-23. doi: 10.1093/nar/gkr388. Epub 2011 May 26.

CoMet--a web server for comparative functional profiling of metagenomes.

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  • 1Department of Bioinformatics, Institute for Microbiology and Genetics, Georg-August University Göttingen, Goldschmidtstr. 1, 37077 Göttingen, Germany. thomas@gobics.de

Abstract

Analyzing the functional potential of newly sequenced genomes and metagenomes has become a common task in biomedical and biological research. With the advent of high-throughput sequencing technologies comparative metagenomics opens the way to elucidate the genetically determined similarities and differences of complex microbial communities. We developed the web server 'CoMet' (http://comet.gobics.de), which provides an easy-to-use comparative metagenomics platform that is well-suitable for the analysis of large collections of metagenomic short read data. CoMet combines the ORF finding and subsequent assignment of protein sequences to Pfam domain families with a comparative statistical analysis. Besides comprehensive tabular data files, the CoMet server also provides visually interpretable output in terms of hierarchical clustering and multi-dimensional scaling plots and thus allows a quick overview of a given set of metagenomic samples.

PMID:
21622656
[PubMed - indexed for MEDLINE]
PMCID:
PMC3125781
Free PMC Article
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