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Front Biosci (Schol Ed). 2011 Jun 1;3:1058-66.

The function of histamine receptor H4R in the brain revealed by interaction partners.

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  • 1Departamento de Biologia Molecular y Bioquimica, Facultad de Ciencias, Campus de Teatinos, Universidad de Malaga, and CIBER de Enfermedades Raras (CIBERER), Valencia, Spain.


The histamine H4 receptor is mainly expressed in haematopoietic cells, hence is linked to inflammatory and immune system conditions. It has been recently discovered that the receptor is expressed also in the mammalian central nervous system (CNS), but its role in the brain remains unclear. We address the potential functions of the histamine H4 receptor in the human brain using a 'guilty by association' logic, by close examination of protein-protein functional associations networks in the human proteome.

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