Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Virol. 1990 Jul;64(7):3541-4.

Infrequent involvement of c-fos in avian leukosis virus-induced nephroblastoma.

Author information

  • 1Department of Pathology, University of Massachusetts Medical Center, Worcester 01655.

Abstract

To determine whether c-fos is involved in avian leukosis virus-induced nephroblastoma, 28 tumors from chickens were analyzed for novel fos fragments. DNA from 1 of 16 clonal outgrowths (in chicken 6561) contained novel fos-related EcoRI and KpnI fragments which hybridized to both v-fos and viral probes. Oncogenicity tests using filtered 6561 tumor cell homogenates did not reveal a tumor-inducing transduction of c-fos. We conclude that c-fos is only an occasional target for proviral insertions or new transductions in avian leukosis virus-induced nephroblastoma. The results also identify a polymorphism in c-fos in K28 chickens and demonstrate that unintegrated viral DNA is not a general characteristic of avian leukosis virus-induced nephroblastoma.

PMID:
2161956
[PubMed - indexed for MEDLINE]
PMCID:
PMC249628
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk