Format

Send to

Choose Destination
See comment in PubMed Commons below
Sci Pharm. 2011 Mar;79(1):1-20. doi: 10.3797/scipharm.1007-15. Epub 2010 Dec 31.

Phytoestrogen biological actions on Mammalian reproductive system and cancer growth.

Author information

  • 1Department of Biology, University of Ottawa, Gendron Hall, 30 Marie Curie, K1N 6N5, Ottawa, ON, Canada.

Abstract

Phytoestrogens are a family of diverse polyphenolic compounds derived from nature plant that structurally or functionally mimic circulating estrogen in the mammalian reproductive system. They induce estrogenic and anti-estrogenic effects in the brain-pituitary-gonad axis (a principal endocrine system involving in reproductive regulation) and peripheral reproductive organs. The dichotomy of phytoestrogen-mediated actions elucidates that they play the biological activities via complex mechanisms and belong to various chemical classes. In comparison with their unobvious physiological functions in normal reproductive tissues, there are increasing investigations showing that phytoestrogen induces significant inhibitory effects on the growth of breast and ovarian cancers through different signaling pathways. This review summarized the results of the previous studies regarding principal signaling transductions for mediating the growth of the ovarian and breast cancers. Phytoestrogen potentially modulates the signaling molecules via: (1) blocking the nuclear and membrane estrogen receptors (ER), (2) interfering with the growth factor receptor, (3) inhibiting the G protein-coupled receptor in ER-deficient cells, (4) activating apoptosis and nullifying anti-apoptotic signals.

KEYWORDS:

Breast Cancer; Estrogen Receptor; Ovarian Cancer; Phytoestrogen

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk