Two new ginkgolides from the leaves of Ginkgo biloba

Planta Med. 2011 Nov;77(16):1818-21. doi: 10.1055/s-0030-1271153. Epub 2011 May 25.

Abstract

Two new diterpenoid compounds, ginkgolide P(1) and ginkgolide Q(2), were isolated from the leaves of Ginkgo biloba L. Their structures were elucidated by various spectroscopic methods, and the structure of 1 was further confirmed by X-ray crystallographic analysis. The activities of the compounds were evaluated against platelet aggregation induced by platelet activating factor (PAF), and the preliminary structure-activity relationship was also discussed.

MeSH terms

  • Animals
  • China
  • Crystallography, X-Ray
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Diterpenes / pharmacology
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Ginkgo biloba / chemistry*
  • Ginkgolides / chemistry
  • Ginkgolides / isolation & purification*
  • Ginkgolides / pharmacology
  • Lactones / chemistry
  • Lactones / isolation & purification
  • Lactones / pharmacology
  • Medicine, Chinese Traditional
  • Plant Leaves / chemistry
  • Plants, Medicinal / chemistry
  • Platelet Activating Factor / drug effects
  • Platelet Aggregation / drug effects
  • Rabbits
  • Structure-Activity Relationship

Substances

  • Diterpenes
  • Drugs, Chinese Herbal
  • Ginkgolides
  • Lactones
  • Platelet Activating Factor
  • ginkgolide P
  • ginkgolide Q