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J Assist Reprod Genet. 2011 Sep;28(10):917-23. doi: 10.1007/s10815-011-9573-1. Epub 2011 May 26.

Identification of common mechanisms between endometriosis and ovarian cancer.

Author information

  • 1Department of Clinical Laboratory, Qianfo Shan Hospital, Shandong University, Jinan, Shandong, People's Republic of China.

Abstract

PURPOSE:

To determine common molecular markers between endometriosis and ovarian cancer.

METHODS:

Patients included women who underwent laparoscopic excision of ovarian endometriotic lesions (n = 7), healthy non-pregnant women with normal pelvises, who underwent excision of normal peritoneum (n = 7). Two epithelial ovarian cancer (EOC) cell lines were also utilized. Expression of transforming growth factor (TGF)-β1, cyclooxygenase (COX)-2, vascular endothelial growth factor (VEGF), estrogen receptor (ER)-1α, progesterone receptor (PR), androgen receptor (AR), and aromatase was evaluated by real-time RT-PCR.

RESULTS:

Endometriosis and EOC cells manifested significantly higher mRNA levels of TGF-β1, COX-2, VEGF, ER-1α, AR, and aromatase, while they expressed significantly lower mRNA levels of PR.

CONCLUSIONS:

Increased TGF-β1, COX-2, VEGF, ER-1α, AR, and aromatase and decreased PR in endometriotic as well as EOC cells suggests a potential association between these two disease processes. This association is important, as it may reveal common mechanisms for both diseases.

PMID:
21614520
[PubMed - indexed for MEDLINE]
PMCID:
PMC3220443
Free PMC Article

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