Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Mucosal Immunol. 2011 Sep;4(5):496-502. doi: 10.1038/mi.2011.22. Epub 2011 May 25.

A role for interleukin-33 in T(H)2-polarized intestinal inflammation?

Author information

  • 1Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, Herlev, Denmark. jseidelin@dadlnet.dk

Abstract

Interleukin 33 (IL-33) is a recently discovered cytokine member of the IL-1 superfamily that is widely expressed in fixed tissue cells, including endothelial and epithelial cells. IL-33 induces helper T cells, mast cells, eosinophils, and basophils to produce type-2 cytokines through binding to the ST2/IL-1 receptor accessory protein complex. Recent studies have shown IL-33 to be upregulated in intestinal parasite infection and in epithelial cells and myofibroblasts in ulcerative colitis (UC). The findings point to a role for IL-33 in directing the T(H)2-type immune responses in these types of mucosal inflammation. As the IL-33/ST2 receptor axis can be manipulated by various blocking antibodies, this could be a potential therapeutic target in the future treatment of UC.

PMID:
21613987
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk